CTO/CSO, RNA Delivery System (LNP)

Founded in 2001 and headquartered in Guangdong, China, Fapon Group is at the forefront of in vitro diagnostic (IVD), biological therapy, and precise diagnosis and treatment. We're expanding globally, and you can be part of our journey. With a core value of 'foresee and prepare for what future demands,' Fapon focuses on raw material solutions, IVD ecosystem platform service, and intelligent digital diagnosis and treatment.

Based on the global industrial ecology, Fapon has established major production and sales (R&D) bases in Beijing, Shenzhen, Shanghai, the United States, India, Singapore, and other locations throughout the world, forming a global R&D, production, marketing, and service network, with products being widely sold to 61 countries and regions. Also, Fapon has R&D bases in Boston, California, and Germany. In IVD core raw material, Fapon is the leading producer in China, South Korea, India, and Brazil. Besides IVD products, Fapon has an 8-year-old pharmaceutical division, mainly focusing on monoclonal antibodies and cellular therapeutics. Its first product, a differentiated CD47 antibody, has received FDA IND approval in Feb 2023 and will start clinical trial soon. It is an important part of Fapon's plan to enter the CGT field and develop medicines for the benefit of human beings.

You can learn more about us by visiting https://en.faponbiotech.com

We are looking for a CTO/CSO, RNA Delivery System (LNP) with a proven track record in biochemical engineering and nanomedicine to lead the development of novel delivery systems for different technology platforms, including mRNA vaccines, therapeutics, siRNA, and in vivo gene editing. As a CSO/CTO/founding partner, you will be responsible for leading a team of experts and technicians to develop a differentiated LNP-based delivery system for RNA.  Join us in shaping the future!

Responsibilities

• Lead a team of experts and technicians to develop a differentiated LNP-based delivery system for RNA
• Collaborate with the RNA team to conduct in vitro and in vivo studies, leading to eventual clinical trials
• Improve upon the current mainstream LNP-based delivery systems, to increase the expression rate, lower the immunogenicity, etc.
• Lead formulation development of mRNA drug targets entailing delivery formulations for in vitro/in vivo studies
• Evaluate novel ideas for RNA delivery systems, including LNP-based systems and non-LNP-based systems
• Develop LNP novel formulations and explore new processes for formulation design, CMC, and large-scale production
• Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams

Minimum Qualifications:

• PhD in Chemistry, Physical Chemistry, Chemical Engineering, or Pharmaceutical Sciences
• 4+ years of industry experience in RNA delivery system R&D with hands-on experience in RNA delivery system development, experience with LNP or other nanoparticles is essential
• Direct experience with RNA encapsulation, quantification, and characterization

Preferred qualifications:

• Demonstrated success in nucleic acid delivery system development with hands-on experience in delivery formulations and characterization
• Experience in developing novel and effective RNA delivery systems, which are differentiated from mainstream LNP delivery systems would be advantageous
• Demonstrated ability to build and manage a research team
• Desire to work in a fast-paced environment dynamic startup environment on cross-functional teams
• Track record of innovative and impactful research including peer-reviewed publications, expertise preferred in vaccine biology, nanoparticle formulation, oval delivery system, targeted therapy using nanoparticle
• Ready to work in a biotech start-up with a founding partner mindset
• Ability to effectively interact and communicate with multidisciplinary scientists, both internally and externally, excellent communication, interpersonal, and presentation skills essential
• Willing to Relocate to Boston or Munich is preferred but not necessary
• Experience with mRNA vaccine development is preferred but not necessary
• An excellent industry networks

What We Offer:

At Fapon US, you can have a good job that can grow into a great career. We offer:

• Financial security through competitive compensation, incentives, and retirement plan
• Health care and well-being programs including competitive medical, dental, vision & medical benefits
• Generous paid time off including vacation, sick time, holidays
• 401(k) retirement savings with a generous company match
• Other comprehensive voluntary benefits include but are not limited to pet insurance, life insurance, employee assistance program (EAP), discount programs, and many more
• The stability of a company with a record of strong financial performance year over year
• Collaborative and supportive work environment

Core values

• Think bigger: Making informed decisions encompassing long-term implications and overall interests.
• Start tomorrow today: Embracing innovation, promoting product launches, and encouraging an environment fostering experiential learning.
• Go bold: Displaying courage, responsibility, and commitment.
• Continue evolving: Embracing active learning and maintaining an open mind.
• Keep it simple: Seeking truth from facts and solving problems efficiently.

About Fapon

Fapon is a global leading life sciences company dedicated to providing integrated solutions and services for diagnostics, biopharma, and biotherapy. Integrating a one-stop solution on raw materials, reagents, and innovative open instrument platforms, the Company has grown into a leading supplier in in-vitro diagnostics. Fapon boasts advanced innovations in therapeutics technologies and AI algorithm platforms with data insights that contribute to a better and healthier world. Supported by its strong global R&D, manufacturing, sales, and service network, Fapon's products have established a presence in 68 countries and regions, serving more than 2,500 business partners worldwide.

Follow us on LinkedIn (Fapon) or visit our website https://en.faponbiotech.com