Principal Scientist, Translational Hematology
- Full-Time
Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
Verve is looking for a Principal Scientist with expertise in translational biology research, specifically in hematology. This individual would be responsible for designing translational and investigative research studies to bridge the gap between early research and clinical studies, thereby supporting the strategic development of gene editing based drug products. This individual will work cross functionally within the nonclinical development team and with the clinical and regulatory teams to provide mechanistic insights and translational capabilities relevant to the development of Verve's gene editing medicines.
Job Responsibilities- Design and coordinate studies to understand the potential effects of gene editing products
- Interpret and report data from investigative and translational studies to drive mechanistic understanding
- In partnership with R&D teams, facilitate appropriate incorporation of translational medicine strategies for early and late phases of development
- Implement and coordinate innovative biomarkers for defined endpoints based on the best available science and emerging multi-omic technologies
- Utilizes literature reviews, protocols, networking, and prior laboratory experience to advance the pre-clinical and clinical goals of the organization
- Author research papers, abstracts, technical reports, and sections of regulatory documents
- Effectively present and communicate research findings to internal and external collaborators, including upper management, regulatory agencies, and at research conferences
- Collaborate with internal and external stakeholders
- Other duties within the nonclinical development department, as assigned
- Ph.D. in biology or associated life science discipline with strong background/experience in hematology
- At least 10 years of relevant experience
- Strong hands-on experience with translational lab methodologies (ex. cell-based techniques, ex-vivo drug testing and models, PK/PD assays)
- Ability to collaborate and influence at all levels across an organization
- Exceptional written and verbal communication allowing oneself to communicate scientific data and information to others in a digestible format
- Analytical mindset and good problem-solving ability
- Demonstrated ability to critically evaluate and contribute to multiple scientific programs
- Diligence and attention to detail
- Good organizational skills
Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing AgenciesVerve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
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